Nagler A, Morecki S, Slavin S
Department of Bone Marrow Transplantation and Cancer Immunobiology, Hadassah University Hospital, Jerusalem, Israel.
Methods Mol Med. 1998;9:329-50. doi: 10.1385/0-89603-396-1:329.
Soybean agglutinin (SBA) is a plant lectin, a glycoprotein of nonimmune origin that binds specifically to cell surface carbohydrates through noncovalent combinations and thus provokes agglutination of the bound cells. SBA has been used, therefore, to fractionate a variety of cell types. SBA binds approx 60-90% of bone marrow mononuclear cells, including mature myeloid, erythroid, and lymphoid cells, but has very low binding affinity and no toxic effect to the human hematopoietic progenitor cells. In addition, it binds very effectively to certain tumor cells, including neuroblastoma, breast cancer, and Burkitt's lymphoma cells. Based on these characteristics, SBA has multiple potential applications for clinical bone marrow, transplantation (BMT).
大豆凝集素（SBA）是一种植物凝集素，一种非免疫来源的糖蛋白，它通过非共价结合特异性地与细胞表面碳水化合物结合，从而引起结合细胞的凝集。因此，SBA已被用于分离多种细胞类型。SBA可结合约60%-90%的骨髓单核细胞，包括成熟的髓系、红系和淋巴细胞，但对人类造血祖细胞的结合亲和力非常低且无毒性作用。此外，它能非常有效地结合某些肿瘤细胞，包括神经母细胞瘤、乳腺癌和伯基特淋巴瘤细胞。基于这些特性，SBA在临床骨髓移植（BMT）中有多种潜在应用。
