Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Vienna, Austria.
Prenat Diagn. 2011 May;31(5):484-90. doi: 10.1002/pd.2724. Epub 2011 Mar 4.
In view of the increasing role of magnetic resonance imaging (MRI) as an adjunct to prenatal ultrasonography (US), this study sought to demonstrate the visualization of fetal akinesia and associated abnormalities on MRI.
This retrospective study included six fetuses with akinesia and associated abnormalities, depicted on fetal MRI after suspicious prenatal US. The whole fetus was assessed for musculoskeletal abnormalities and associated pathological conditions elsewhere. Fetal outcome data were compared with prenatal imaging. US and MRI findings were also compared.
Akinesia resulting in arthrogryposis was seen in 6/6 fetuses, with abnormal musculature in 5/6 fetuses. Associated brain abnormalities were found in 2/6 fetuses; facial abnormalities in 3/6; lung hypoplasia in 3/6; and polyhydramnios in 2/6. There were 5/6 pregnancies that were terminated and one individual died neonatally. MRI and brain autopsy were concordant in 4/6 cases. MRI and body autopsy were concordant in 1/6 cases and in 5/6 cases, autopsy revealed additional abnormalities. In addition to US, MRI correctly identified central nervous system findings in four cases and lung hypoplasia in three cases.
Our MRI results demonstrate fetal akinesia and associated abnormalities, which may have an impact on perinatal management, as an adjunct to prenatal US.
鉴于磁共振成像（MRI）在产前超声检查（US）中的辅助作用日益增加，本研究旨在展示 MRI 对胎儿运动障碍及其相关异常的可视化。
本回顾性研究纳入了 6 例胎儿运动障碍及其相关异常的病例，这些病例均在可疑产前 US 后通过胎儿 MRI 显示。对整个胎儿进行了骨骼肌肉异常和其他部位相关病理情况的评估。将胎儿结局数据与产前影像学结果进行了比较，并对 US 和 MRI 的检查结果进行了比较。
6 例胎儿均出现导致关节弯曲的运动障碍，5 例胎儿存在异常肌肉。2 例胎儿存在脑部异常；3 例胎儿存在面部异常；3 例胎儿存在肺发育不全；2 例胎儿存在羊水过多。6 例中有 5 例终止妊娠，1 例新生儿死亡。4 例 MRI 和脑部尸检结果一致，1 例 MRI 和全身尸检结果一致，而在 5 例中，尸检发现了其他异常。除 US 外，MRI 还正确识别了 4 例中枢神经系统异常和 3 例肺发育不全。
我们的 MRI 结果展示了胎儿运动障碍及其相关异常，这可能对产前 US 有影响，有助于围产期管理。
