Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.
Small. 2011 Apr 4;7(7):841-56. doi: 10.1002/smll.201001389. Epub 2011 Feb 25.
The discovery of RNA interference has revitalized the long ongoing pursuit of gene therapy for the treatment of diseases. Nevertheless, despite promising results from experimental studies, there remains a pressing need for the development of nanocarriers that are clinically-relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add-ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery.
RNA 干扰的发现为治疗疾病的基因治疗的长期持续追求注入了新的活力。然而，尽管实验研究取得了有希望的结果，但仍然迫切需要开发临床相关、生物相容、高效的纳米载体，并针对特定的疾病靶点进行定制。本综述调查了广泛的纳米材料及其功能添加剂，并旨在为有效 siRNA 传递的纳米载体工程提供指导。
