Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr H S Gour University, Sagar, MP, India.
Biomaterials. 2012 Oct;33(29):7138-50. doi: 10.1016/j.biomaterials.2012.06.068. Epub 2012 Jul 12.
Increasing knowledge about molecular mechanisms of endogenous RNA interference (RNAi) and small interfering RNAs (siRNAs) has been incorporated into innovative nucleic acid medicines for treatment of diseases such as cancers. Although RNAi and siRNA have the potential to become powerful therapeutic drugs, their delivery to the target site represents a major challenge. The design and creation of nanocarriers for the safe and efficient delivery of siRNA towards their potential applications site is one of the challenging and rapidly growing areas of research since they have to overcome the commonly encountered biological barriers. In this review, we discuss the recent nanotechnological strategies for siRNA delivery by using different carriers such as liposomes, dendrimers and carbon nanotubes.
越来越多的人开始了解内源性 RNA 干扰（RNAi）和小干扰 RNA（siRNA）的分子机制，并将其应用于癌症等疾病的创新核酸药物治疗中。尽管 RNAi 和 siRNA 具有成为强大治疗药物的潜力，但将其递送至靶位仍然是一个巨大的挑战。设计和创造纳米载体以实现 siRNA 的安全有效的递送至其潜在应用部位是极具挑战性且快速发展的研究领域之一，因为它们必须克服常见的生物屏障。在本文中，我们讨论了利用不同载体（如脂质体、树枝状聚合物和碳纳米管）进行 siRNA 递送的最新纳米技术策略。
