Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Antioxid Redox Signal. 2011 Jul 1;15(1):147-51. doi: 10.1089/ars.2011.3968. Epub 2011 May 25.
Increases in hydrogen peroxide can initiate protective responses to limit or repair oxidative damage. However, hydrogen peroxide signals also fine-tune responses to growth factors and cytokines to control cell division, differentiation, and migration. Here we discuss some of the mechanisms by which hydrogen peroxide is sensed and utilized as a signaling molecule to regulate diverse biological processes. We also discuss how the localization and levels of hydrogen peroxide, antioxidants, and the cellular metal composition together influence the nature of the response.
过氧化氢的增加可以启动保护反应，以限制或修复氧化损伤。然而，过氧化氢信号也可以微调对生长因子和细胞因子的反应，以控制细胞分裂、分化和迁移。在这里，我们讨论了一些过氧化氢被感知和用作信号分子来调节多种生物过程的机制。我们还讨论了过氧化氢、抗氧化剂的定位和水平以及细胞金属组成如何共同影响反应的性质。
