AP-HP, Hôpital Européen Georges Pompidou, Service de Microbiologie, Paris, France.
Clin Microbiol Infect. 2011 Aug;17(8):1264-7. doi: 10.1111/j.1469-0691.2010.03454.x. Epub 2011 Mar 7.
In clinical studies on bacteraemia, the negativity of blood cultures is an important endpoint for comparing the efficacy of different therapeutic regimens. In FAN anaerobic blood culture medium (BacT/ALERT system), daptomycin displayed increased MIC against Staphylococcus aureus and improved abolishment of its carryover effect in charcoal when compared with vancomycin. Differences between these two drugs can lead to a false interpretation of negative blood cultures. To compare different antibiotic regimens for the treatment of bacteraemia, preliminary studies are mandatory to ensure that ex vivo antibiotic behaviour is similar in the blood-culture system used.
在菌血症的临床研究中，血培养的阴性结果是比较不同治疗方案疗效的一个重要终点。在 FAN 厌氧血培养介质（BacT/ALERT 系统）中，与万古霉素相比，达托霉素对金黄色葡萄球菌的 MIC 值增加，并且其在活性炭上的携带效应得到改善。这两种药物之间的差异可能导致对血培养阴性结果的错误解释。为了比较不同抗生素方案治疗菌血症的效果，必须进行初步研究，以确保在所用的血培养系统中，体外抗生素行为相似。
