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缺氧诱导的微小RNA-449a/b下调削弱了对靶向丝氨酸蛋白酶抑制剂E1（PAI-1）mRNA的调控——这是一种与丝氨酸蛋白酶抑制剂E1（PAI-1）过表达相关的机制。

Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression.

作者信息

Muth Michaela, Hussein Kais, Jacobi Christoph, Kreipe Hans, Bock Oliver

机构信息

Institute of Pathology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

出版信息

J Transl Med. 2011 Mar 4;9:24. doi: 10.1186/1479-5876-9-24.

DOI:10.1186/1479-5876-9-24
PMID:21375729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3066127/
Abstract

After publication of our article 1, we realized the need for posting a correction note in order to prevent i) overinterpretation of some results by the readers and ii) concerns about potentially unintended misguidance by the authors.

摘要

在我们的文章1发表后，我们意识到有必要发布一份更正说明，以防止：i）读者对某些结果过度解读；ii）作者担心可能会无意中造成误导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27c/3066127/f4bce3e3474b/1479-5876-9-24-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27c/3066127/ba948570cd3e/1479-5876-9-24-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27c/3066127/f557f3e04e7f/1479-5876-9-24-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27c/3066127/c970a703fe22/1479-5876-9-24-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27c/3066127/f4bce3e3474b/1479-5876-9-24-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27c/3066127/ba948570cd3e/1479-5876-9-24-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27c/3066127/f557f3e04e7f/1479-5876-9-24-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27c/3066127/c970a703fe22/1479-5876-9-24-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27c/3066127/f4bce3e3474b/1479-5876-9-24-4.jpg

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本文引用的文献

1
"Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression".“低氧诱导的 microRNA-449a/b 下调损害了对靶向 SERPINE1(PAI-1)mRNA 的控制——这是 SERPINE1(PAI-1)过表达的一种机制”。
J Transl Med. 2010 Apr 1;8:33. doi: 10.1186/1479-5876-8-33.
Oncoscience. 2014 Nov 15;1(11):674-705. doi: 10.18632/oncoscience.98. eCollection 2014.
4
MicroRNAs and the cancer phenotype: profiling, signatures and clinical implications.微小RNA与癌症表型：分析、特征及临床意义
Genome Med. 2013 Dec 30;5(12):111. doi: 10.1186/gm516. eCollection 2013.
5
Hypoxia: a master regulator of microRNA biogenesis and activity.缺氧：miRNA 生物发生和活性的主控因子。
Free Radic Biol Med. 2013 Sep;64:20-30. doi: 10.1016/j.freeradbiomed.2013.05.022. Epub 2013 May 24.
6
MicroRNAs and lung cancers: from pathogenesis to clinical implications.微小 RNA 与肺癌：从发病机制到临床意义。
Front Med. 2012 Jun;6(2):134-55. doi: 10.1007/s11684-012-0188-4. Epub 2012 Apr 18.
7
Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells.缺氧诱导的 microRNA-34a 下调通过靶向管状上皮细胞中的 Notch 信号通路促进 EMT。
PLoS One. 2012;7(2):e30771. doi: 10.1371/journal.pone.0030771. Epub 2012 Feb 17.
8
The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer.miR-143/-145 簇调节膀胱癌中的纤溶酶原激活物抑制剂-1。
Br J Cancer. 2012 Jan 17;106(2):366-74. doi: 10.1038/bjc.2011.520. Epub 2011 Nov 22.