State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
J Colloid Interface Sci. 2011 May 15;357(2):280-5. doi: 10.1016/j.jcis.2011.01.109. Epub 2011 Mar 4.
Luminescent, mesoporous, and bioactive europium-doped calcium silicate (MCS: Eu) was successfully synthesized. The obtained MCS: Eu(3+) was performed as a drug delivery carrier to investigate the drug storage/release properties using ibuprofen (IBU) as the model drug. The structural, morphological, textural, and optical properties were well characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), N(2) adsorption/desorption, and photoluminescence (PL) spectra, respectively. The results reveal that the MCS: Eu exhibits the typical ordered characteristics of the mesostructure. This composite shows a sustained release profile with IBU as the model drug. The IBU-loaded samples still present red luminescence of Eu(3+) ((5)D(0)-(7)F(1,2)) under UV irradiation. The emission intensities of Eu(3+) in the drug carrier system vary with the amount of released IBU, making the drug release easily tracked and monitored. The system demonstrates a great potential for drug delivery and disease therapy.
成功合成了发光、介孔且生物活性的铕掺杂硅酸钙（MCS：Eu）。所得的 MCS：Eu(3+) 被用作药物输送载体，以布洛芬（IBU）为模型药物研究药物储存/释放性能。通过 X 射线衍射（XRD）、透射电子显微镜（TEM）、N2 吸附/脱附以及光致发光（PL）光谱分别对其结构、形态、织构和光学性质进行了很好的表征。结果表明，MCS：Eu 表现出介孔结构的典型有序特征。该复合材料显示出以 IBU 为模型药物的持续释放特性。负载 IBU 的样品在紫外光照射下仍呈现 Eu(3+)((5)D0-(7)F1,2)的红色发光。药物载体系统中 Eu(3+)的发射强度随释放的 IBU 量而变化，使得药物释放易于跟踪和监测。该体系在药物输送和疾病治疗方面具有很大的潜力。
