Hou Zhiyao, Yang Piaoping, Lian Hongzhou, Wang Lili, Zhang Cuimiao, Li Chunxia, Chai Ruitao, Cheng Ziyong, Lin Jun
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Chemistry. 2009 Jul 13;15(28):6973-82. doi: 10.1002/chem.200900269.
Luminescent, mesoporous, and bioactive europium-doped hydroxyapatite (HAp:Eu(3+)) nanofibers and microbelts have been prepared by a combination of sol-gel and electrospinning processes with a cationic surfactant as template. The obtained multifunctional hydroxyapatite nanofibers and microbelts, which have mesoporous structure and red luminescence, were tested as drug carriers by investigating their drug-storage/release properties with ibuprofen (IBU) as model drug. X-ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution (HR) TEM, FTIR spectroscopy, N(2) adsorption/desorption, photoluminescence (PL) spectra, and UV/Vis spectroscopy were used to characterize the structural, morphological, textural, and optical properties of the resulting samples. The results reveal that the multifunctional hydroxyapatites exhibit irregular mesostructure, and have fiberlike and beltlike morphologies with sizes of several hundred nanometers in width and several millimeters in length. The IBU-loaded HAp:Eu(3+) system shows red luminescence of Eu(3+) ((5)D(0)-(7)F(0,1,2)) under UV irradiation and controlled release of IBU. In addition, the emission intensity of Eu(3+) in the drug carrier system varies with the released amount of IBU, and thus drug release can be easily tracked and monitored by the change in luminescence intensity.
采用溶胶 - 凝胶法与静电纺丝法相结合，并以阳离子表面活性剂为模板，制备了发光、介孔且具有生物活性的铕掺杂羟基磷灰石（HAp:Eu(3+)）纳米纤维和微带。通过以布洛芬（IBU）为模型药物研究其药物储存/释放性能，对所得具有介孔结构和红色发光的多功能羟基磷灰石纳米纤维和微带作为药物载体进行了测试。利用X射线衍射、扫描电子显微镜（SEM）、透射电子显微镜（TEM）、高分辨率（HR）TEM、傅里叶变换红外光谱（FTIR）、N₂吸附/脱附、光致发光（PL）光谱和紫外/可见光谱对所得样品的结构、形态、织构和光学性质进行了表征。结果表明，多功能羟基磷灰石呈现不规则介观结构，具有纤维状和带状形态，宽度为几百纳米，长度为几毫米。负载IBU的HAp:Eu(3+)体系在紫外光照射下显示出Eu(3+)的红色发光（(5)D(0)-(7)F(0,1,2)）以及IBU的控释。此外，药物载体体系中Eu(3+)的发射强度随IBU释放量而变化，因此通过发光强度的变化可轻松跟踪和监测药物释放。
