纤溶酶原激活剂：药理学与治疗学
Plasminogen activators: pharmacology and therapy.
作者信息
Holden R W
机构信息
Department of Radiology, Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis 46202.
出版信息
Radiology. 1990 Mar;174(3 Pt 2):993-1001. doi: 10.1148/radiology.174.3.174-3-993.
Abstract
Biochemical advances are providing new insights into coagulation and fibrinolysis. Integrating this biochemical knowledge into plasminogen activator therapy improves understanding of currently available enzymes. Basic components of the fibrinolytic system are discussed and the chemical structures, pharmacokinetics, dosages, and modes of delivery of current and future plasminogen activators are reviewed.
摘要
生化进展为凝血和纤溶提供了新的见解。将这些生化知识整合到纤溶酶原激活剂治疗中，有助于更好地理解目前可用的酶。本文讨论了纤溶系统的基本组成部分，并综述了当前和未来纤溶酶原激活剂的化学结构、药代动力学、剂量及给药方式。
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