Department of Polymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University, 4800 Caoan Road, Shanghai, 201804, China.
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Drug Deliv Transl Res. 2021 Aug;11(4):1323-1339. doi: 10.1007/s13346-021-00963-0. Epub 2021 Mar 24.
Ultrasound-responsive polymeric materials have received a tremendous amount of attention from scientists for several decades. Compared to other stimuli-responsive materials (such as UV-, thermal-, and pH-responsive materials), these smart materials are more applicable since they allow more efficient drug delivery and targeted treatment by fairly non-invasive means. This review describes the recent advances of such ultrasound-responsive polymer-based drug delivery systems and illustrates various applications. More specifically, the mechanism of ultrasound-induced drug delivery, typical formulations, and biomedical applications (tumor therapy, disruption of blood-brain barrier, fighting infectious diseases, transdermal drug delivery, and enhanced thrombolysis) are summarized. Finally, a perspective on the future research directions for the development of ultrasound-responsive polymeric materials to facilitate a clinical translation is given.
超声响应型聚合物材料在过去几十年中受到了科学家们的极大关注。与其他刺激响应性材料（如 UV、热和 pH 响应性材料）相比，这些智能材料更具适用性，因为它们可以通过相当非侵入性的方式更有效地进行药物输送和靶向治疗。本文综述了超声响应型聚合物基药物输送系统的最新进展，并举例说明了各种应用。更具体地说，本文总结了超声诱导药物输送的机制、典型制剂以及生物医学应用（肿瘤治疗、破坏血脑屏障、抗感染、经皮药物输送和增强溶栓）。最后，对超声响应型聚合物材料未来的研究方向进行了展望，以促进其临床转化。
