Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Vet Parasitol. 2011 Jun 30;179(1-3):250-2. doi: 10.1016/j.vetpar.2011.01.051. Epub 2011 Feb 2.
Cryptosporidium is an intestinal parasite associated with severe acute diarrhea in humans and animals. To investigate subtypes of Cryptosporidium spp. isolated from humans and cattle in Iran, 47 Cryptosporidium parvum (22 from children and 25 from cattle) and three Cryptosporidium hominis from children were characterized by sequence analysis of the 60 kDa glycoprotein (gp60) gene. Nine subtypes (two of C. hominis and seven of C. parvum) in four subtype families were identified. Cattle were mainly infected with C. parvum IIa subtypes and humans mostly with the C. parvum IIa and IId subtypes. Consequently, cattle could be a source of human infection with C. parvum IIa in Iran. However, the occurrence of subtype IId families in Iranian children, suggests that other infection sources might also be involved in C. parvum transmission. To our knowledge, this is the first published record and description of Cryptosporidium subtypes in Iran.
隐孢子虫是一种与人类和动物严重急性腹泻有关的肠道寄生虫。为了研究伊朗从人和牛分离的隐孢子虫种的亚型，对 47 株微小隐孢子虫（22 株来自儿童，25 株来自牛）和 3 株来自儿童的人隐孢子虫进行了 60 kDa 糖蛋白（gp60）基因序列分析。在四个亚型家族中鉴定出九个亚型（两种人隐孢子虫和七种微小隐孢子虫）。牛主要感染微小隐孢子虫 IIa 亚型，而人类主要感染微小隐孢子虫 IIa 和 IId 亚型。因此，牛可能是伊朗人感染微小隐孢子虫 IIa 的来源。然而，伊朗儿童中出现 IId 家族，表明其他感染源也可能参与隐孢子虫的传播。据我们所知，这是伊朗首次发表的隐孢子虫亚型的记录和描述。
