Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei 230022, Anhui, China.
Burns. 2011 Aug;37(5):794-9. doi: 10.1016/j.burns.2011.01.003. Epub 2011 Mar 3.
Keloids are common abnormal raised fibroproliferative lesions that can occur following even minor cutaneous trauma. Human leukocyte antigen (HLA) polymorphisms have shown strong association with susceptibility to keloids with different ethnic backgrounds. In this study, the polymerase chain reaction sequence-specific primer method was used to analyze the distribution of HLA haplotype in 192 patients with keloids and 252 healthy control individuals. Controls were matched by gender, age, and race. We compared haplotype between the two groups, and analyzed their association with keloids. The haplotype analysis revealed that three new two-locus haplotypes including B07-DQB10501, B07-DRB115, DQB10503-DRB115 (P<0.05) were associated with keloids, while two extended haplotypes B07-Cw0802-DQB10501 (P=0.0063) and Cw0802-DQB10501-DRB115 (P=0.0121) were found to be related to keloids. This is the first detailed report to elucidate HLA haplotypes associated with keloids. Our results provide some information for future research on predisposing genes in major histocompatibility complex (MHC) regions in Chinese patients with keloids. In addition, the association of certain HLA haplotypes with susceptibility to keloids would provide clues in choosing proper preventive strategies.
瘢痕疙瘩是一种常见的异常隆起性纤维增生性病变，即使是轻微的皮肤创伤也可能导致其发生。人类白细胞抗原（HLA）多态性与不同种族背景下瘢痕疙瘩的易感性有很强的关联。在这项研究中，采用聚合酶链反应序列特异性引物法分析了 192 例瘢痕疙瘩患者和 252 例健康对照者的 HLA 单倍型分布。对照者按性别、年龄和种族匹配。我们比较了两组之间的单倍型，并分析了它们与瘢痕疙瘩的关系。单倍型分析显示，包括 B07-DQB10501、B07-DRB115 和 DQB10503-DRB115 在内的三个新的双基因座单倍型（P<0.05）与瘢痕疙瘩相关，而两个扩展单倍型 B07-Cw0802-DQB10501（P=0.0063）和 Cw0802-DQB10501-DRB115（P=0.0121）也与瘢痕疙瘩相关。这是第一个详细报告阐明与瘢痕疙瘩相关的 HLA 单倍型的研究。我们的研究结果为中国瘢痕疙瘩患者主要组织相容性复合体（MHC）区域中易感基因的进一步研究提供了一些信息。此外，某些 HLA 单倍型与瘢痕疙瘩易感性的关联为选择适当的预防策略提供了线索。
