Grups J W, Frohmüller H G
Department of Urology, University of Wurzburg Medical School, F.R. Germany.
Urology. 1990 Feb;35(2):111-3. doi: 10.1016/0090-4295(90)80054-q.
Natural killer (NK) cell stimulation can be repeatedly elicited by cyclic administration of recombinant human interferon (rHu IFN) gamma in patients with metastatic renal cell cancer. In all cycles of treatment, the elevation of the cytolytic activity of the NK cells was statistically significant. The shift of the T4/T8 ratio (T-helper/T-suppressor lymphocytes) a short time after the commencement of IFN application might be a manifestation of the immunostimulation induced.
在转移性肾细胞癌患者中，通过重组人干扰素（rHu IFN）γ的循环给药可反复引发自然杀伤（NK）细胞刺激。在所有治疗周期中，NK细胞的细胞溶解活性升高具有统计学意义。在开始应用干扰素后短时间内T4/T8比值（辅助性T细胞/抑制性T细胞淋巴细胞）的变化可能是诱导免疫刺激的一种表现。
