Yamada J, Tanaka N, Kamitani S, Goto K, Gangi J, Orita K
Gan To Kagaku Ryoho. 1986 May;13(5):1946-52.
We administered recombinant gamma-interferon (ReIFN-gamma) daily to 7 cancer patients, and the effect on the immune function of peripheral blood lymphocytes was studied. Following the administration of ReIFN-gamma, no characteristic changes were observed in leukocyte count, lymphocyte count, OKT4/OKT8 or Leu 7. Natural killer cell cytotoxicity was augmented in all cases from the first week of administration and retained a high level of activity during the period of treatment. In contrast, the blastogenesis of PBL with PHA decreased from the first week. Suppressor cell activity was augmented from the first week and maintained throughout this period. As to clinical effect, two patients who had metastatic liver tumors showed a response to the administration of ReIFN-gamma.
我们对7例癌症患者每日给予重组γ干扰素（ReIFN-γ），并研究其对外周血淋巴细胞免疫功能的影响。给予ReIFN-γ后，白细胞计数、淋巴细胞计数、OKT4/OKT8或Leu 7均未观察到特征性变化。从给药第一周起，所有病例的自然杀伤细胞细胞毒性均增强，并在治疗期间保持较高的活性水平。相反，从第一周起，PHA刺激的外周血淋巴细胞增殖反应降低。从第一周起抑制细胞活性增强，并在此期间一直维持。至于临床疗效，2例有肝转移瘤的患者对ReIFN-γ给药有反应。
