Fraunhofer Institute for Biomedical Engineering, Am Muehlenberg 13, Potsdam 14476, Germany.
Talanta. 2011 Apr 15;84(2):274-9. doi: 10.1016/j.talanta.2010.12.049. Epub 2011 Jan 13.
Molecularly imprinted polymers (MIPs) for the recognition of nitro derivatives are prepared from three different (thio)urea-bearing functional monomers. The binding capability of the polymers is characterized by a batch binding experiment. The imprinting factors and affinity constants (K) of the imprinted polymers exhibit the same tendency as the binding constants (K(a)) of the functional monomers to the target substance in solution. Not only nitrofurantoin is efficiently bound by these MIPs but also a broad spectrum of other nitro compounds is bound with at the intermediate level, addressing that these (thio)urea-based monomers can be utilized to prepare a family of MIPs for various nitro compounds, which can be applied as recognition elements in separation and analytical application.
基于三种不同的（硫）脲功能单体，制备了用于识别硝基衍生物的分子印迹聚合物（MIPs）。通过批量结合实验来表征聚合物的结合能力。印迹因子和印迹聚合物的亲和常数（K）与目标物质在溶液中的功能单体的结合常数（K(a)）表现出相同的趋势。这些 MIPs 不仅能有效结合硝基呋喃妥因，还能中等程度地结合广谱的其他硝基化合物，表明这些基于（硫）脲的单体可用于制备一系列用于各种硝基化合物的 MIPs，可作为分离和分析应用中的识别元件。
