Department of Radiology, University of Occupational and Environmental Health School of Medicine, Kitakyushu 807-8555, Japan.
Psychiatry Res. 2011 Apr 30;192(1):55-9. doi: 10.1016/j.pscychresns.2010.10.011. Epub 2011 Mar 5.
Working conditions such as shift work constitute a well-known risk factor for insomnia and excessive daytime sleepiness complaints. We compared brain gamma-aminobutyric acid (GABA), glutamic acid (Glu), glutamine (Gln), and Glx (Glu+Gln) levels in day-shift versus alternate-shift workers with proton magnetic resonance spectroscopy ((1)H-MRS) at 3T. The study population consisted of 32 healthy adult volunteers (16 day-shift and 16 alternate-shift workers). Each subject underwent MRS conducted using a MEGA-PRESS sequence in the early morning and early evening on the same day. Spectroscopy voxels (3.0 cm × 3.0 cm × 3.0 cm) were placed in the frontal lobe and parieto-occipital lobe. The GABA/Cr ratio in the frontal lobe was significantly lower for the alternate-shift group than for the day-shift group in the early evening (1.885 vs. 0.875). For the other metabolite ratios (Gln/Cr and Glx/Cr), there were no significant differences between the two groups regardless of morning or evening schedule. Our preliminary finding represents a possible alteration of GABA content in the brain related to an irregular work schedule.
工作条件，如轮班工作，是失眠和白天过度嗜睡投诉的一个众所周知的风险因素。我们比较了在 3T 质子磁共振波谱仪((1)H-MRS)下，白天班和倒班工人的脑γ-氨基丁酸(GABA)、谷氨酸(Glu)、谷氨酰胺(Gln)和 Glx(Glu+Gln)水平。研究人群由 32 名健康成年志愿者组成(16 名白天班和 16 名倒班工人)。每位受试者均在同一天的清晨和傍晚，使用 MEGA-PRESS 序列进行 MRS 检查。光谱体素(3.0 cm×3.0 cm×3.0 cm)放置在前额叶和顶枕叶。与白天班相比，倒班组在傍晚时的额叶 GABA/Cr 比值明显更低(1.885 对 0.875)。对于其他代谢物比值(Gln/Cr 和 Glx/Cr)，无论上午还是傍晚的时间表，两组之间均无显著差异。我们的初步发现代表了与不规则工作时间表相关的大脑中 GABA 含量的可能改变。
