Department of Neurosurgery, Tampere University Hospital, Teiskontie 35, 33521 Tampere, Finland.
Seizure. 2011 Jul;20(6):438-41. doi: 10.1016/j.seizure.2011.01.018. Epub 2011 Mar 5.
Cardiolipin (CL) and β(2)-Glycoprotein I (β(2)-GpI) antibodies have been shown to associate with various neurological symptoms including seizures and cognitive dysfunction. Here we studied the prevalence of CL, β(2)-GpI and antinuclear (ANA) antibodies in 74 patients with various developmental disorders with epilepsy and 70 healthy controls. Developmental disorders were classified into genetic syndromes and diseases, genetic and/or acquired conditions, cortical dysgenesias and acquired encephalopathias. IgM-CL and β(2)-GpI antibodies were significantly more common in patients (46% vs. 20%, p<0.001 and 10% vs. 0%, p<0.05). Patients with most frequent seizures were more likely to have IgM-CL antibodies. The risk for positive IgM-CL, IgG-CL and β(2)-GpI antibodies increased concomitantly with increasing intellectual disability. Present data demonstrates that epilepsy with frequently recurring seizures may be associated with secondary immune system activation.
心磷脂 (CL) 和 β(2)-糖蛋白 I (β(2)-GpI) 抗体已被证明与各种神经系统症状相关，包括癫痫发作和认知功能障碍。在这里，我们研究了 74 例伴有癫痫的各种发育障碍患者和 70 例健康对照者中 CL、β(2)-GpI 和抗核 (ANA) 抗体的患病率。发育障碍分为遗传综合征和疾病、遗传和/或获得性疾病、皮质发育不良和获得性脑病。IgM-CL 和 β(2)-GpI 抗体在患者中更为常见（46%比 20%，p<0.001 和 10%比 0%，p<0.05）。癫痫发作最频繁的患者更有可能出现 IgM-CL 抗体。IgM-CL、IgG-CL 和 β(2)-GpI 抗体阳性的风险随着智力障碍的增加而增加。目前的数据表明，频繁发作的癫痫可能与继发性免疫系统激活有关。
