Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan.
Anticancer Res. 2011 Feb;31(2):507-14.
Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia.
To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n = 222), and quantitative reverse-transcriptase polymerase chain reaction (n = 151).
ADM was a novel independent prognostic factor for CRC (p = 0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p < 0.0001) and vascular endothelial growth factor (p < 0.0001) in vivo.
ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.
最近，我们使用结直肠癌（CRC）肝转移的缺氧肿瘤细胞在体内确定了几个潜在的预后因素。其中，肾上腺髓质素（ADM）的表达是一个有趣的靶点，因为它受到缺氧的高度诱导。
为了评估 ADM 表达的预后影响，我们通过微阵列（n = 222）和定量逆转录聚合酶链反应（n = 151）分析了总共 373 例 CRC 患者的样本。
ADM 是 CRC 的一个新的独立预后因素（p = 0.027）。ADM 表达与体内缺氧诱导因子-1A（p < 0.0001）和血管内皮生长因子（p < 0.0001）相关。
ADM 表达是预测 CRC 患者根治性切除后复发和癌症相关死亡高风险的有用标志物。
