Department of Internal Medicine, Dong-A University College of Medicine, Seo-gu, Busan, Republic of Korea.
Anticancer Res. 2010 Oct;30(10):4163-8.
The principal objective of this study was to evaluate the prognostic significances of p53, hypoxia inducible factor-1 alpha (HIF-1α), and vascular endothelial growth factor (VEGF) expression in colorectal cancer.
The tumor tissues of 311 patients with colorectal carcinoma that had undergone potentially curative resections were immunohistochemically assessed using monoclonal antibodies against p53, HIF-1α, and VEGF.
Positivity rates of p53, HIF-1α, and VEGF were 42.4%, 63.0%, and 56.6%, respectively. HIF-1α expression in tumor tissues was determined to be correlated significantly with the expression of VEGF (p=0.040), and depth of invasion (p=0.019). Multivariate analysis demonstrated that HIF-1α was independently associated with poor overall survival (p=0.002).
HIF-1α expression is associated with VEGF expression and angiogenesis in colorectal carcinoma. Additionally, the expression of HIF-1α in tumor tissue is associated with angiogenesis and poor overall survival in patients with colorectal cancer.
本研究的主要目的是评估结直肠癌中 p53、缺氧诱导因子-1α（HIF-1α）和血管内皮生长因子（VEGF）表达的预后意义。
采用针对 p53、HIF-1α 和 VEGF 的单克隆抗体，对 311 例接受根治性切除术的结直肠癌患者的肿瘤组织进行免疫组织化学评估。
p53、HIF-1α 和 VEGF 的阳性率分别为 42.4%、63.0%和 56.6%。肿瘤组织中 HIF-1α 的表达与 VEGF 的表达（p=0.040）和浸润深度（p=0.019）显著相关。多因素分析表明，HIF-1α 与总生存期不良独立相关（p=0.002）。
HIF-1α 表达与结直肠癌中的 VEGF 表达和血管生成有关。此外，肿瘤组织中 HIF-1α 的表达与结直肠癌患者的血管生成和总生存期不良有关。
