Rice Quantum Institute, Rice University, Houston, TX, USA.
J Breath Res. 2011 Mar;5(1):016003. doi: 10.1088/1752-7155/5/1/016003. Epub 2011 Jan 11.
The extended exhaled nitric oxide (eNO) parameters, including peripheral or alveolar eNO, are investigational biomarkers in COPD. In this study, the hypothesis was tested that elevated peripheral eNO correlates with decreased functional capacity and lower global health status. Twenty-seven subjects with the Global Initiative for Chronic Obstructive Lung Disease stage 3 and 4 COPD were enrolled. Functional capacity and health status were tested using the 6 min walk test and St George's Respiratory Questionnaire (SGRQ) respectively. eNO parameters were estimated using multiple exhalation flow rates and were corrected for axial diffusion. The extended NO measurements were FE(NO)0.05 14.2 ppb (range 5.1-23.2), C(ANO) 4.6 ppb (2.2-6.9), D(awNO) 8.8 ml s(-1) (4.8-12.9), C(awNO) 83.2 ppb (29.9-128.7) and J'(awNO) 405 pl s(-1) (111-731). The distance traveled in the 6 min walk test was correlated with peripheral nitric oxide (r = -0.59, p = 0.03). SGRQ symptom score was correlated with maximum airway NO flux (r = -0.73, p = 0.01). SGRQ total score was correlated with maximum airway NO flux (r = -0.56, p = 0.05). In this study of subjects with severe COPD, peripheral nitric oxide correlated with functional capacity while large airway NO parameters correlated with symptom scores.
外周或肺泡呼出气一氧化氮（eNO）等扩展的 eNO 参数是 COPD 的研究性生物标志物。在这项研究中，提出了一个假设，即外周 eNO 升高与功能能力下降和整体健康状况降低相关。共招募了 27 名患有 GOLD 3 期和 4 期 COPD 的患者。使用 6 分钟步行测试和圣乔治呼吸问卷（SGRQ）分别测试功能能力和健康状况。使用多次呼气流速估计 eNO 参数，并进行轴向扩散校正。扩展的 NO 测量值为 FE（NO）0.05 14.2 ppb（范围 5.1-23.2）、C（ANO）4.6 ppb（2.2-6.9）、D（awNO）8.8 ml s（-1）（4.8-12.9）、C（awNO）83.2 ppb（29.9-128.7）和 J'（awNO）405 pl s（-1）（111-731）。6 分钟步行试验中行走的距离与外周一氧化氮呈负相关（r = -0.59，p = 0.03）。SGRQ 症状评分与最大气道 NO 通量呈负相关（r = -0.73，p = 0.01）。SGRQ 总分与最大气道 NO 通量呈负相关（r = -0.56，p = 0.05）。在这项对严重 COPD 患者的研究中，外周一氧化氮与功能能力相关，而大气道 NO 参数与症状评分相关。
