Fernandez de Castro M, Salas S, Martinez A, Larrocha C, Viloria A, Jimenez M C
LaPaz Hospital, Madrid, Spain.
Am J Pediatr Hematol Oncol. 1990 Spring;12(1):71-3. doi: 10.1097/00043426-199021000-00013.
A transient leukemoid reaction in a neonate with Down syndrome is reported. The blastic proliferation was identified as T lymphoblastic in an early stage of maturation (prethymocytes) using morphological, cytochemical, and immunological methods. A spontaneous complete remission occurred in 8 weeks. No additional cytogenetic alterations were found, except for those concerning chromosome 21. Other cases reported in the literature reveal that cytogenetic studies may be useful to distinguish these transient leukemic reactions from true leukemias in newborns with Down syndrome. The in vitro growth pattern of peripheral blood and bone marrow may also be useful for this purpose.
报告了1例患有唐氏综合征的新生儿出现短暂性类白血病反应。在成熟早期（前胸腺细胞），通过形态学、细胞化学和免疫学方法将原始细胞增殖鉴定为T淋巴细胞母细胞。8周内出现自发完全缓解。除了与21号染色体有关的改变外，未发现其他细胞遗传学改变。文献中报道的其他病例表明，细胞遗传学研究可能有助于区分这些短暂性白血病反应与唐氏综合征新生儿的真性白血病。外周血和骨髓的体外生长模式也可能有助于此目的。
