Neonatal Intensive Care Unit, S. Maria della Misericordia Hospital of Perugia, S. Andrea delle Fratte, 06156, Perugia, Italy.
Eur J Pediatr. 2011 Aug;170(8):1075-8. doi: 10.1007/s00431-011-1422-9. Epub 2011 Mar 8.
Premature infants with preterm premature rupture of membranes (PPROM) are at high risk of severe respiratory failure because of lung hypodysplasia associated with persistent pulmonary hypertension of the newborn (PPHN). We describe the clinical course of a 28-week gestation infant with PPROM from the 20th week and prolonged oligohydramnios before delivery, who developed refractory hypoxia treated with oral bosentan as adjunct therapy to inhaled nitric oxide (iNO) and oral sildenafil. Conclusion Our experience suggests that bosentan can be used in the premature infant with PPHN after PPROM. To the best of our knowledge, this is the first report of bosentan treatment in a premature infant.
患有胎膜早破（PPROM）的早产儿由于与新生儿持续性肺动脉高压（PPHN）相关的肺发育不全而有发生严重呼吸衰竭的高风险。我们描述了一名 28 周妊娠的婴儿的临床病程，该婴儿从第 20 周开始发生胎膜早破，分娩前出现长时间羊水过少，在接受吸入一氧化氮（iNO）和口服西地那非辅助治疗的基础上，因难治性缺氧而加用口服波生坦。结论：我们的经验表明，在患有 PPHN 的早产儿中可以使用波生坦。据我们所知，这是首例关于早产儿使用波生坦的报告。
