Malova E S, Balmasova I P, Iuschuk N D, Shmeleva E V, Eremina O F
Zh Mikrobiol Epidemiol Immunobiol. 2010 Nov-Dec(6):48-52.
To study functional activity of natural killers on different stages of fibrosis during chronic hepatitis C.
Functional activity of CD3-/CD56+/CD16+ lymphocytes measured as expression of natural killers receptors (NKR) and natural cytotoxicity receptors (NCR) was assessed by flow cytometry.
At stage I of fibrosis, decrease of number of CD3-/CD56+/NKG2D+ cells was observed, whereas at precirrhotic stage III--sharp decrease of CD3-/CD56+/CD94+ and CD3-/ CD56+/NKG2D+ populations, and at cirrhotic stage--decrease of number of CD3-/CD56+/ NKG2D+ cells and increase of cytolytic activity of natural killers carrying CD107a marker compared to precirrhotic stage.
Obtained data demonstrate that natural killers during chronic hepatitis C receive regulatory signals mainly through lectin type receptors (CD94 and NKG2D).
研究慢性丙型肝炎纤维化不同阶段自然杀伤细胞的功能活性。
通过流式细胞术评估以自然杀伤细胞受体（NKR）和自然细胞毒性受体（NCR）表达来衡量的CD3⁻/CD56⁺/CD16⁺淋巴细胞的功能活性。
在纤维化I期，观察到CD3⁻/CD56⁺/NKG2D⁺细胞数量减少，而在肝硬化前期III期，CD3⁻/CD56⁺/CD94⁺和CD3⁻/CD56⁺/NKG2D⁺群体急剧减少，在肝硬化期，与肝硬化前期相比，CD3⁻/CD56⁺/NKG2D⁺细胞数量减少，且携带CD107a标记的自然杀伤细胞的细胞溶解活性增加。
获得的数据表明，慢性丙型肝炎期间自然杀伤细胞主要通过凝集素型受体（CD94和NKG2D）接收调节信号。
