[慢性丙型肝炎期间自然杀伤细胞凝集素型受体表达与肝纤维化程度之间的关联]
[Association between expression of lectin type receptors by natural killers and intensity of liver fibrosis during chronic hepatitis C].
作者信息
Malova E S, Balmasova I P, Iuschuk N D, Shmeleva E V, Eremina O F
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 2010 Nov-Dec(6):48-52.
AIM
To study functional activity of natural killers on different stages of fibrosis during chronic hepatitis C.
MATERIALS AND METHODS
Functional activity of CD3-/CD56+/CD16+ lymphocytes measured as expression of natural killers receptors (NKR) and natural cytotoxicity receptors (NCR) was assessed by flow cytometry.
RESULTS
At stage I of fibrosis, decrease of number of CD3-/CD56+/NKG2D+ cells was observed, whereas at precirrhotic stage III--sharp decrease of CD3-/CD56+/CD94+ and CD3-/ CD56+/NKG2D+ populations, and at cirrhotic stage--decrease of number of CD3-/CD56+/ NKG2D+ cells and increase of cytolytic activity of natural killers carrying CD107a marker compared to precirrhotic stage.
CONCLUSION
Obtained data demonstrate that natural killers during chronic hepatitis C receive regulatory signals mainly through lectin type receptors (CD94 and NKG2D).
目的
研究慢性丙型肝炎纤维化不同阶段自然杀伤细胞的功能活性。
材料与方法
通过流式细胞术评估以自然杀伤细胞受体（NKR）和自然细胞毒性受体（NCR）表达来衡量的CD3⁻/CD56⁺/CD16⁺淋巴细胞的功能活性。
结果
在纤维化I期，观察到CD3⁻/CD56⁺/NKG2D⁺细胞数量减少，而在肝硬化前期III期，CD3⁻/CD56⁺/CD94⁺和CD3⁻/CD56⁺/NKG2D⁺群体急剧减少，在肝硬化期，与肝硬化前期相比，CD3⁻/CD56⁺/NKG2D⁺细胞数量减少，且携带CD107a标记的自然杀伤细胞的细胞溶解活性增加。
结论
获得的数据表明，慢性丙型肝炎期间自然杀伤细胞主要通过凝集素型受体（CD94和NKG2D）接收调节信号。
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