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一种预测人工髋关节中聚乙烯磨损的新公式。

A new formulation for the prediction of polyethylene wear in artificial hip joints.

作者信息

Liu F, Galvin A, Jin Z, Fisher J

机构信息

Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK.

出版信息

Proc Inst Mech Eng H. 2011 Jan;225(1):16-24. doi: 10.1243/09544119JEIM819.

Abstract

Artificial joints employing ultra-high molecular weight polyethylene (UHMWPE) are widely used to treat joint diseases and trauma. Wear of the polymer bearing surface largely limits the use of these joints in younger and more active patients. Previous studies have shown the wear factor used in Archard's law for the conventional polyethylene to be highly dependent on contact pressure and this has produced variability in experimental data and has constrained the reliability and applicability of previous computational predictions. A new wear law is proposed, based on wear volume being dependent on, and proportional to, the product of the sliding distance and contact area. The dimensionless proportional constant, wear coefficient, which was independent of contact pressure, was determined from a multi-directional pin on plate study. This was used in computational predictions of the wear of the conventional UHMWPE hip joints. The wear of the polyethylene cup was independently experimentally determined in physiological full hip joint simulator studies. The predicted wear rate from the new computational model was generally increased, with an improved agreement with the experimental measurement compared with the previous computational model. It was shown that wear in the UHMWPE hip joints increased as head size and contact area increased. This resulted in a much larger increase in the wear rate as the head size increased, compared with the previous computational model, and is consistent with clinical observations. This new understanding of the wear mechanism in artificial joints using the UHMWPE bearing surfaces, and the improved ability to predict wear independently and to address previously described discrepancies offer new opportunities to optimize design parameters.

摘要

采用超高分子量聚乙烯(UHMWPE)的人工关节被广泛用于治疗关节疾病和创伤。聚合物承载表面的磨损在很大程度上限制了这些关节在年轻且活动较多的患者中的使用。先前的研究表明,阿查德定律中用于传统聚乙烯的磨损因子高度依赖于接触压力,这导致实验数据存在变异性,并限制了先前计算预测的可靠性和适用性。基于磨损体积取决于滑动距离和接触面积的乘积且与之成比例,提出了一种新的磨损定律。通过多向销盘试验确定了与接触压力无关的无量纲比例常数——磨损系数。该系数用于传统UHMWPE髋关节磨损情况的计算预测。在生理全髋关节模拟器研究中独立地通过实验测定了聚乙烯髋臼杯的磨损情况。与先前的计算模型相比,新计算模型预测的磨损率总体上有所增加,且与实验测量结果的一致性得到了改善。结果表明,随着股骨头尺寸和接触面积的增加,UHMWPE髋关节的磨损也会增加。与先前的计算模型相比,这导致随着股骨头尺寸增加,磨损率的增加幅度要大得多,且与临床观察结果一致。对使用UHMWPE承载表面的人工关节磨损机制的这种新理解,以及独立预测磨损和解决先前所述差异的能力的提高,为优化设计参数提供了新的机会。

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