Haider Nighat, Nagi Abdul Ghaffar, Khan Khalid Mehmood A
Department of Paediatric Medicine, National Institute of Child Health, Karachi.
J Pak Med Assoc. 2010 Sep;60(9):729-32.
To determine the frequency of nutritional rickets in children hospitalized with severe pneumonia.
This study was carried out at the department of paediatric medicine at National Institute of Child Health Karachi. It is a case series done over a period of six months from 15th November 2008 to 15th may 2009. Patients admitted (n=137) with severe pneumonia were included in the study and were investigated for presence of rickets with serum calcium, phosphorus and alkaline phosphatase. Those having low to normal calcium low phosphorus and raised alkaline phosphatase were labeled as having rickets. All data collected were entered on Performa. Children with familial, vitamin D dependent/resistant rickets, secondary rickets, and cerebral palsy or on anti convulsant therapy were excluded from this study.
Out of 137 patients, with severe pneumonia, 83 were male and 54 female. Frequency of nutritional rickets in children with severe pneumonia was observed in 101(74%) cases. Rickets was more common in 2 to 12 months of age, i.e., 79.8% (67/84) and in those children who were breast fed (85.3% vs. 40%). Frequency was higher in those children who were not exposed to sunlight.
Pneumonia is a very common presentation of rickets. This study suggests that rickets may be more common in children who are breast fed and those who have less exposure to sunlight.
确定因重症肺炎住院儿童中营养性佝偻病的发生率。
本研究在卡拉奇国家儿童健康研究所儿科进行。这是一项病例系列研究,时间跨度为2008年11月15日至2009年5月15日的六个月。纳入研究的是因重症肺炎入院的患者(n = 137),通过检测血清钙、磷和碱性磷酸酶来调查是否存在佝偻病。钙水平低至正常、磷水平低且碱性磷酸酶升高的患者被标记为患有佝偻病。所有收集的数据都录入了表格。本研究排除了患有家族性、维生素D依赖性/抵抗性佝偻病、继发性佝偻病、脑瘫或正在接受抗惊厥治疗的儿童。
137例重症肺炎患者中,男性83例,女性54例。101例(74%)重症肺炎儿童中观察到营养性佝偻病。佝偻病在2至12个月大的儿童中更常见,即79.8%(67/84),且在母乳喂养的儿童中更常见(85.3%对40%)。未接受阳光照射的儿童中发生率更高。
肺炎是佝偻病的一种非常常见的表现形式。本研究表明,佝偻病在母乳喂养的儿童和阳光照射较少的儿童中可能更常见。