Shah Tanveer Hussain, Hassan Mukhtiar, Siddiqui Tahir Saeed
Department of Biochemistry and Health Sciences, Hazara University, Mansehra, KPK.
Department of Paediatric, Ayub Medical College and Teaching Hospital, Abbottabad.
J Coll Physicians Surg Pak. 2014 Sep;24(9):663-5.
To determine the occurrence of subclinical rickets and its causing factors among adolescent students of schools in Kaghan Valley, Pakistan.
Observation cross-sectional study.
Department of Biochemistry and Health Sciences, Hazara University, Mansehra, Ayub Medical College and Teaching Hospital, Abbottabad, from March to April 2012.
Sixty seven students (34 boys and 33 girls) age between 11 - 16 years included in the study from different schools of Kaghan Valley, Pakistan. Characteristic, serum biochemical and nutritional status were measured for all the participants. On the basis of biochemical finding the boys and girls students were divided in to two groups, normal subjects and subclinical rickets (absent symptoms with altered biochemistry).
Twenty six participants, 19 (73%) girls and 07 (27%) boys had biochemical abnormality but no clinical signs and symptoms of rickets. Low vitamin D and high alkaline phosphatase level were observed in 26 (100%), 21 (81%), low calcium in 17 (65%) and low phosphorus 7 (27%) subjects with subclinical rickets. None had high parathormone level above normal range. Nutritional intake of calcium, phosphorus and vitamin D was found less than the recommended daily intake in all the participants.
Subclinical rickets is common problem among adolescent students especially in girls which is due to low nutritional intakes and avoidance of sunshine due to environmental and traditional impacts.
确定巴基斯坦卡干山谷地区学校青少年学生中亚临床佝偻病的发生率及其影响因素。
观察性横断面研究。
2012年3月至4月,在哈扎拉大学(位于曼塞赫拉)生物化学与健康科学系、阿伯塔巴德的阿尤布医学院及教学医院开展研究。
从巴基斯坦卡干山谷地区不同学校选取67名年龄在11至16岁之间的学生(34名男生和33名女生)纳入研究。对所有参与者进行特征、血清生化及营养状况测量。根据生化检查结果,将男女生分为两组,即正常受试者和亚临床佝偻病组(无临床症状但生化指标异常)。
26名参与者存在生化异常但无佝偻病临床体征和症状,其中19名(73%)为女生,7名(27%)为男生。亚临床佝偻病患者中,26名(100%)维生素D水平低,21名(81%)碱性磷酸酶水平高,17名(65%)钙水平低,7名(27%)磷水平低。无人甲状旁腺激素水平高于正常范围。所有参与者的钙、磷和维生素D营养摄入量均低于推荐每日摄入量。
亚临床佝偻病是青少年学生尤其是女生中的常见问题,这是由于营养摄入不足以及环境和传统因素导致的日照不足所致。