Naqvi Imama, Murtaza Muhammad, Nazir Muhammad Ressam, Naqvi Haider Ali
Class of 2010, Medical College, The Aga Khan University, Karachi, Pakistan.
J Pak Med Assoc. 2010 Oct;60(10):886-9.
To validate the effect of gender on age at onset of schizophrenia in a developing country.
Medical records of 252 patients diagnosed with schizophrenia according to DSM-IV criteria at a tertiary care hospital in Karachi, Pakistan between 2002 and 2008 were reviewed using a structured questionnaire. Age at onset was defined as age at onset of psychotic symptoms, age at first contact with a health care provider and age at first hospitalization. Socio-demographic variables were reported using descriptive statistics and all measures of age at onset were compared across gender using t-test.
There were 119 women and 133 men with mean age of 37.6 +/- 12.8 years. All three measures of age at onset of illness showed no difference between women and men. The mean age when first psychotic symptoms appeared in men was 24.86 +/- 8.83 years (n = 128) while that in women was 26.57 +/- 9.96 years (n = 111), p = 0.160. The mean age at index hospitalization for treatment of psychosis in men was 29.50 +/- 10.64 years (n = 123) and in women was 31.61 +/- 12.07 years (n = 103), p = 0.164. The mean age at first contact with any caregiver in men was 29.73 +/- 37.58 years (n = 119) and in women was 29.38 +/- 11.99 years (n = 108), p = 0.926.
There is no significant difference in age at onset of schizophrenia across gender in our population. This validates a difference in epidemiology of schizophrenia in the South Asian population.
验证性别对一个发展中国家精神分裂症发病年龄的影响。
使用结构化问卷对2002年至2008年间在巴基斯坦卡拉奇一家三级护理医院根据《精神疾病诊断与统计手册》第四版标准诊断为精神分裂症的252例患者的病历进行回顾。发病年龄定义为出现精神病症状的年龄、首次与医疗服务提供者接触的年龄以及首次住院的年龄。使用描述性统计报告社会人口统计学变量，并使用t检验比较各性别发病年龄的所有测量指标。
有119名女性和133名男性，平均年龄为37.6±12.8岁。疾病发病年龄的所有三个测量指标在女性和男性之间均无差异。男性首次出现精神病症状的平均年龄为24.86±8.83岁（n = 128），而女性为26.57±9.96岁（n = 111），p = 0.160。男性因精神病接受治疗的首次住院平均年龄为29.50±10.64岁（n = 123），女性为31.61±12.07岁（n = 103），p = 0.164。男性首次与任何护理人员接触的平均年龄为29.73±37.58岁（n = 119），女性为29.38±11.99岁（n = 108），p = 0.926。
在我们的人群中，精神分裂症发病年龄在性别上没有显著差异。这验证了南亚人群中精神分裂症流行病学的差异。
