通过路易斯酸催化 3-乙氧基环丁酮与单取代腙的反应，合成了一系列吡唑。
A new synthesis of pyrazoles through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines.
机构信息
Department of Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China.
出版信息
Org Lett. 2011 Apr 1;13(7):1746-9. doi: 10.1021/ol2002682. Epub 2011 Mar 7.
PMID:21381639
Abstract
A new efficient and convenient approach toward the synthesis of pyrazoles is described. Through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines, a variety of pyrazole derivatives were prepared readily at ambient temperature with complete regioselectivity.
摘要
描述了一种新的有效且方便的吡唑类合成方法。通过路易斯酸催化的 3-乙氧基环丁酮与单取代腙的缩合反应，在环境温度下以完全区域选择性简便地制备了各种吡唑衍生物。
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