立体选择性直接胺催化脱羧醛醇加成反应。
Stereoselective direct amine-catalyzed decarboxylative aldol addition.
机构信息
Department of Chemistry, Humboldt-University, Brook-Taylor Str. 2, 12 489 Berlin, Germany.
出版信息
Org Lett. 2011 Apr 1;13(7):1878-80. doi: 10.1021/ol200412r. Epub 2011 Mar 7.
PMID:21381691
Abstract
A stereoselective decarboxylative aldol addition of β- and α-keto acids in the presence of catalytic amounts of amines is described. By the optional deployment of chiral enolizable aldehydes an access to enantiopure configurative defined ketopentoses, ketohexoses, or ketoheptoses is given.
摘要
本文描述了在催化量的胺存在下，β-和α-酮酸的立体选择性脱羧醛醇加成反应。通过可选地使用手性烯醇化醛，可获得对映纯构型定义的酮戊糖、酮己糖或酮庚糖。
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