Klaus M V, Wehr R F, Rogers R S, Russell T J, Krochmal L
Dermatology Section, Veteran Administration Medical Center, Buffalo, NY.
J Am Acad Dermatol. 1990 Feb;22(2 Pt 1):199-203. doi: 10.1016/0190-9622(90)70023-b.
A double-blind, paired comparison study was used to evaluate treatment effects of 12% ammonium lactate lotion (Lac-Hydrin) against its vehicle on seborrheic keratoses. Fifty-eight volunteer patients, 37 to 82 years of age, were studied for 16 weeks. The patients had a minimum of two seborrheic keratoses at least 10 cm apart. They applied the medication twice daily. The lesions were evaluated for height, surface characteristics, color, and length with the use of 7X calibrated loupe, a template, skin replicas, and scanning electron microscopy. Lac-Hydrin 12% lotion significantly reduced the height (elevation) of seborrheic keratoses, and two seborrheic keratoses cleared completely; however, there was no statistically significant difference in the length, color, and surface characteristics between the study group and the control group. Skin replicas and scanning electron microscopy can be used to evaluate lesion surface characteristics, dimensions, and therapeutic effects.
一项双盲、配对比较研究用于评估12%乳酸铵洗剂（Lac-Hydrin）相对于其赋形剂对脂溢性角化病的治疗效果。对58名年龄在37至82岁的志愿者患者进行了为期16周的研究。患者至少有两个相距至少10厘米的脂溢性角化病。他们每天涂抹两次药物。使用7倍校准放大镜、模板、皮肤复制品和扫描电子显微镜对皮损的高度、表面特征、颜色和长度进行评估。12% Lac-Hydrin洗剂显著降低了脂溢性角化病的高度（隆起），并且有两个脂溢性角化病完全消退；然而，研究组和对照组在长度、颜色和表面特征方面没有统计学上的显著差异。皮肤复制品和扫描电子显微镜可用于评估皮损的表面特征、尺寸和治疗效果。
