Shelley W B, Shelley E D, Burmeister V
J Am Acad Dermatol. 1987 Jan;16(1 Pt 1):124-8. doi: 10.1016/s0190-9622(87)80175-5.
An ultrastructural study of five seborrheic keratoses arising in a symmetrical, patterned distribution following the lines of cleavage on the backs of two patients showed the presence of melanosome macrocomplexes 2 to 5 microns in size. Identical findings were seen in fifteen pigmented seborrheic keratoses randomly distributed on the skin of five patients. The membrane-bound macrocomplexes were clusters of closely packed, discrete melanosomes. Present in melanocytes, keratinocytes, Langerhans cells, and dermal macrophages, they were considered to result from sequestration of melanosomes in cell phagosomes. No homogeneous inclusions typical of melanin macroglobules ("giant melanosomes") were found in any of the specimens, supporting the view that neither patterned nor nonpatterned seborrheic keratoses are nevoid in nature.
对两名患者背部沿分裂线呈对称、有图案分布出现的5个脂溢性角化病进行的超微结构研究显示，存在大小为2至5微米的黑素体大复合体。在随机分布于5名患者皮肤上的15个色素性脂溢性角化病中也观察到了相同的结果。膜结合大复合体是紧密堆积的离散黑素体簇。它们存在于黑素细胞、角质形成细胞、朗格汉斯细胞和真皮巨噬细胞中，被认为是黑素体被细胞吞噬体隔离的结果。在任何标本中均未发现典型的黑色素大球（“巨大黑素体”）的均匀内含物，这支持了有图案或无图案的脂溢性角化病在本质上都不是痣样的观点。
