希腊帕特雷地区 30 年来儿童哮喘患病率的性别趋势。

Sex-specific trends in prevalence of childhood asthma over 30 years in Patras, Greece.

机构信息

Respiratory Unit, Department of Paediatrics, University Hospital of Patras, School of Medicine of the University of Patras, Rion, Patras, Greece.

出版信息

Acta Paediatr. 2011 Jul;100(7):1000-5. doi: 10.1111/j.1651-2227.2011.02255.x. Epub 2011 Mar 29.

DOI:10.1111/j.1651-2227.2011.02255.x

PMID:21382080

Abstract

AIM

According to four surveys conducted during 1978-2003, the prevalence of childhood asthma and wheezing has risen in the city of Patras, Greece, albeit at a decelerating rate. We examined sex-specific wheeze and asthma prevalence in the same urban environment in 2008.

METHODS

A cross-sectional parental questionnaire survey was performed in 2008 among third and fourth grade schoolchildren (8-9 year old), which was identical to previously conducted surveys in 1978 (n = 3003), 1991 (n = 2417), 1998 (n = 3076) and 2003 (n = 2725).

RESULTS

The prevalence of current wheeze and asthma in 1978, 1991, 1998, 2003 and 2008 (n = 2688) was 1.5%, 4.6%, 6.0%, 6.9% and 6.9%, respectively (p for trend <0.001). Respective values for lifetime (ever had) wheeze and asthma in the 1991-2008 surveys were 8.0%, 9.6%, 12.4% and 12.6% (p for trend <0.001). The male:female ratio of current and lifetime wheeze and asthma increased during the 30-year surveillance period (p for trend <0.001). Irrespective of sex, diagnosed asthma declined among current wheezers by 17% (p < 0.001), but not among non-current ones (6.7%, p = 0.16) during 2003-2008.

CONCLUSIONS

Childhood wheeze and asthma have reached a plateau in an urban environment in Greece, while the male:female ratio increased. Asthma diagnosis declined among schoolage but not preschool wheezers during 2003-2008.

摘要

目的

根据 1978 年至 2003 年进行的四项调查，希腊帕特雷市儿童哮喘和喘息的患病率有所上升，但上升速度有所放缓。我们在 2008 年同一城市环境中检查了特定性别喘息和哮喘的患病率。

方法

2008 年对三年级和四年级的小学生（8-9 岁）进行了横断面家长问卷调查，该调查与 1978 年（n=3003）、1991 年（n=2417）、1998 年（n=3076）和 2003 年（n=2725）进行的先前调查相同。

结果

1978 年、1991 年、1998 年、2003 年和 2008 年（n=2688）当前喘息和哮喘的患病率分别为 1.5%、4.6%、6.0%、6.9%和 6.9%（趋势 p<0.001）。1991 年至 2008 年调查中终生（曾经有过）喘息和哮喘的相应值分别为 8.0%、9.6%、12.4%和 12.6%（趋势 p<0.001）。在 30 年的监测期间，当前和终生喘息和哮喘的男女比例增加（趋势 p<0.001）。无论性别如何，2003-2008 年期间，当前喘息者中确诊哮喘的比例下降了 17%（p<0.001），而非当前喘息者则没有下降（6.7%，p=0.16）。