Hanami Yuka, Motoki Yoshikazu, Yamamoto Toshiyuki
Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Dermatol Online J. 2011 Feb 15;17(2):6.
Plasma cell cheilitis is an uncommon chronic inflammatory dermatitis that presents with flat to slightly elevated erosive erythematous plaques. It is histologically characterized by plasma cell infiltrates into the mucosa. Other than the lip, genital areas are often involved, which is called plasma cell balanitis or vulvitis. Plasma cell cheilitis is sometimes resistant to conventional topical corticosteroid therapy. Other choices include oral griseofulvin, topical cyclosporine, and intralesional corticosteroid injection, all of which occasionally fail to produce satisfactory results. Recent reports show that topical calcineurin inhibitors are effective for plasma cell cheilitis, balanitis, and vulvitis. However, there are so far only 2 reports of plasma cell cheilitis successfully treated with topical pimecrolimus and tacrolimus. We present herein two cases of plasma cell cheilitis, in which topical tacrolimus showed beneficial effects, suggesting that this immunomodulatory agent is a promising option for plasma cell cheilitis.
浆细胞性唇炎是一种罕见的慢性炎症性皮肤病，表现为扁平至轻度隆起的糜烂性红斑斑块。其组织学特征为浆细胞浸润黏膜。除唇部外，生殖器部位也常受累，称为浆细胞性龟头炎或外阴炎。浆细胞性唇炎有时对传统外用糖皮质激素治疗有抵抗性。其他治疗选择包括口服灰黄霉素、外用环孢素和皮损内注射糖皮质激素，但所有这些治疗偶尔都无法产生满意的效果。最近的报告显示，外用钙调神经磷酸酶抑制剂对浆细胞性唇炎、龟头炎和外阴炎有效。然而，迄今为止，仅有2例浆细胞性唇炎外用吡美莫司和他克莫司成功治疗的报告。我们在此报告2例浆细胞性唇炎病例，外用他克莫司显示出有益效果，提示这种免疫调节剂是治疗浆细胞性唇炎的一个有前景的选择。
