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肉芽肿性酒渣鼻:表现为孤立性斑块的不寻常病例。

Granulomatous rosacea: unusual presentation as solitary plaque.

作者信息

Batra Mayanka, Bansal Cherry, Tulsyan Suman

出版信息

Dermatol Online J. 2011 Feb 15;17(2):9.

PMID:21382292
Abstract

A 45-year-old male presented with a 6 month history of an enlarging smooth, erythematous plaque over the central part of his face. Mild erythema of both eyes was present. Sarcoidosis, Hansen disease, lupus vulgaris, cutaneous leishmaniasis, pseudolymphoma, foreign body granuloma, granuloma faciale, discoid lupus erythematosus, and granulomatous rosacea were considered in the differential diagnosis. CBC, urinalysis, renal function tests, liver function tests, serum electrolytes, and blood sugar were all normal. Chest X-ray and ECG revealed no abnormality. Serology for syphilis and HIV, and mantoux test were negative. Slit-skin smear, tissue smear and culture for AFB and fungi were negative. Skin biopsy revealed multiple non-caseating epitheloid granulomas around the pilosebaceous unit suggestive of granulomatous rosacea. Granulomatous rosacea, a rare entity comprising only about 10 percent of cases of rosacea can mimic many granulomatous conditions both clinically and histologically making the diagnosis an enigma. It usually presents as yellowish brown-red discrete papules on the face; non-caseating epithelioid granulomas are seen on histology examination. We herein report the case because it presented in atypical fashion, as a solitary indurated plaque on the nose, likely representing Morbihan's disease or solid persistent facial edema of rosacea (rosacea lymphedema).

摘要

一名45岁男性,面部中央有一个逐渐增大的光滑、红斑性斑块,病史6个月。双眼有轻度红斑。鉴别诊断考虑了结节病、麻风病、寻常狼疮、皮肤利什曼病、假性淋巴瘤、异物肉芽肿、面部肉芽肿、盘状红斑狼疮和肉芽肿性酒渣鼻。血常规、尿常规、肾功能检查、肝功能检查、血清电解质和血糖均正常。胸部X线和心电图未见异常。梅毒和HIV血清学检查以及结核菌素试验均为阴性。抗酸杆菌和真菌的皮肤涂片、组织涂片及培养均为阴性。皮肤活检显示围绕皮脂腺单位有多个非干酪样上皮样肉芽肿,提示肉芽肿性酒渣鼻。肉芽肿性酒渣鼻是一种罕见的疾病,仅占酒渣鼻病例的约10%,在临床和组织学上可模仿许多肉芽肿性疾病,这使得诊断成为一个谜。它通常表现为面部黄褐色至红色的离散丘疹;组织学检查可见非干酪样上皮样肉芽肿。我们在此报告该病例,因为它以非典型方式呈现,表现为鼻子上的单个硬结性斑块,可能代表莫尔比昂病或酒渣鼻的实性持续性面部水肿(酒渣鼻性淋巴水肿)。

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Granulomatous rosacea: unusual presentation as solitary plaque.肉芽肿性酒渣鼻:表现为孤立性斑块的不寻常病例。
Dermatol Online J. 2011 Feb 15;17(2):9.
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Atypical rosacea in a male patient: case study.男性患者的非典型玫瑰痤疮:病例研究
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A case of granulomatous rosacea: sorting granulomatous rosacea from other granulomatous diseases that affect the face.1例肉芽肿性酒渣鼻:鉴别肉芽肿性酒渣鼻与其他累及面部的肉芽肿性疾病。
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Granulomatous rosacea in infants. Report of three cases and discussion of the differential diagnosis.婴儿肉芽肿性酒渣鼻。三例报告及鉴别诊断讨论。
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Lupus miliaris disseminatus faciei: a distinctive rosacea-like syndrome and not a granulomatous form of rosacea.面部播散性粟粒性狼疮:一种独特的酒渣鼻样综合征,而非酒渣鼻的肉芽肿形式。
Dermatology. 2003;206(2):120-3. doi: 10.1159/000068457.

引用本文的文献

1
Morbihan Disease: A Rare Case of Periorbital Bilateral Edema with Histopathological Findings of Chronic Inflammation and Demodex Localization.莫比汉病:眶周双侧水肿的罕见病例,具有慢性炎症和蠕形螨定位的组织病理学发现。
Am J Case Rep. 2024 Jun 14;25:e943421. doi: 10.12659/AJCR.943421.
2
Treatment of Morbihan disease.莫尔比昂病的治疗。
Arch Craniofac Surg. 2021 Jun;22(3):131-134. doi: 10.7181/acfs.2021.00185. Epub 2021 Jun 25.
3
Severe Granulomatous Rosacea with Cutaneous Lupus Erythematosus.伴有皮肤红斑狼疮的重度肉芽肿性酒渣鼻
J Clin Aesthet Dermatol. 2021 Feb;14(2):22-24. Epub 2021 Feb 1.
4
Morbihan disease: A diagnostic dilemma: two cases with successful resolution.莫尔比昂病:诊断难题——两例成功解决的病例
SAGE Open Med Case Rep. 2021 Jun 11;9:2050313X211023655. doi: 10.1177/2050313X211023655. eCollection 2021.