Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, New York, USA.
J Clin Psychiatry. 2011 Feb;72(2):e05. doi: 10.4088/JCP.9096tx4cc.
Data from neurobiologic and psychosocial outcomes research suggest that, phenomenologically, clinically, and neurobiologically, patients with schizoaffective disorder occupy an intermediate position between more severely disturbed schizophrenia patients and similarly or less severely impaired affective disorder patients. Some biologic-genetic abnormalities are shared between these disorders, while other abnormalities are specific to particular symptoms. Premorbid functioning, especially in academic areas, is better in patients with schizoaffective disorder than in those with schizophrenia, but negative symptoms and cognitive deficits are influential and should be addressed to improve psychosocial outcomes.
神经生物学和心理社会结局研究的数据表明，从现象学、临床和神经生物学角度来看，精神分裂情感障碍患者处于更为严重的精神分裂症患者和同样或轻度受损的情感障碍患者之间的中间位置。这些障碍之间存在一些共同的生物学-遗传学异常，而其他异常则是特定症状所特有的。与精神分裂症患者相比，精神分裂情感障碍患者的病前功能更好，尤其是在学术领域，但阴性症状和认知缺陷具有影响力，应该加以解决，以改善心理社会结局。
