Department of Psychiatry, University of Toronto, Ontario, Canada.
J Clin Psychiatry. 2011 Feb;72(2):e06. doi: 10.4088/JCP.9089tx1cc.
Bipolar disorder is a common, chronic, multidimensional syndrome that appears to be a progressive illness, in that each episode substantially increases the risk that another episode will occur and will be less responsive to treatment than previous episodes. The biphasic and episodic nature of bipolar disorder substantially contributes to its negative impact on patients' quality of life as well as their physical, social, and occupational functioning. Patients with bipolar disorder often have co-occurring conditions, particularly medical comorbidities, and, unfortunately, several psychotropic medications prescribed to treat bipolar disorder may increase the risk of developing certain medical illnesses. Although the recommendation in psychiatric care is to regularly assess patients' physical health, many clinicians are not yet implementing this strategy in their clinical practice. When making evidence-based medication choices, clinicians can select from several FDA-approved agents for the treatment of acute manic and depressive episodes as well as for maintenance therapy. Additionally, psychotherapies are effective when used in combination with pharmacotherapy.
双相情感障碍是一种常见的、慢性的、多维的综合征，似乎是一种进行性疾病，因为每次发作都会大大增加下一次发作的风险，并且对治疗的反应不如以前的发作。双相情感障碍的双相和发作性特征极大地影响了患者的生活质量，以及他们的身体、社会和职业功能。双相情感障碍患者通常伴有共病，特别是合并躯体疾病，不幸的是，几种用于治疗双相情感障碍的精神药物可能会增加某些躯体疾病的风险。尽管精神科护理的建议是定期评估患者的身体健康，但许多临床医生尚未在临床实践中实施这一策略。在做出基于证据的药物选择时，临床医生可以从几种 FDA 批准的药物中选择，用于治疗急性躁狂和抑郁发作以及维持治疗。此外，心理治疗与药物治疗联合使用时是有效的。
