College of Environmental Science and Engineering, Hunan University, Changsha 410082, China.
FEBS Lett. 2011 Apr 6;585(7):1072-6. doi: 10.1016/j.febslet.2011.03.005. Epub 2011 Mar 4.
Compound microsatellites consisting of two or more repeats in close proximity have been found in eukaryotic genomes. So far such compound microsatellites have not been investigated in any prokaryotic genomes. We have therefore examined compound microsatellites in 22 complete genomes of Escherichia coli, which is one of the ideal model organisms to analyze the nature and evolution of prokaryotic compound microsatellites. Our results indicated that about 1.75-2.85% of all microsatellites could be accounted as compound microsatellites with very low complexity, and most compound microsatellites were composed of very different motifs. Compound microsatellites were significantly overrepresented in all surveyed genomes. These results were dramatically different from those in eukaryotes. We discussed the possible reasons for the observed divergence.
真核生物基因组中存在由两个或多个紧密相邻重复组成的复合微卫星。到目前为止，还没有在任何原核生物基因组中研究过这种复合微卫星。因此，我们检查了 22 个完整的大肠杆菌基因组中的复合微卫星，大肠杆菌是分析原核复合微卫星的性质和进化的理想模式生物之一。我们的结果表明，大约 1.75-2.85%的所有微卫星可以被认为是具有非常低复杂性的复合微卫星，并且大多数复合微卫星由非常不同的基序组成。复合微卫星在所有被调查的基因组中都显著过表达。这些结果与真核生物的结果有很大的不同。我们讨论了观察到的分歧的可能原因。
