Centre for Academic Surgery, GI Physiology Unit, Barts and The London Queen Mary's School of Medicine and Dentistry, London, UK.
Best Pract Res Clin Gastroenterol. 2011 Feb;25(1):59-71. doi: 10.1016/j.bpg.2010.12.003.
Chronic constipation is a highly debilitating condition, affecting a significant proportion of the community. The burden to the health care system and impact on individual patients quality of life is immense. Unfortunately, the aetiology underlying chronic constipation is poorly understood and animal models are being used increasingly to investigate possible intrinsic neurogenic and myogenic mechanisms leading to relevant colonic sensori-motor dysfunction. Recently, major advances have been made in our understanding of the mechanisms that underlie propagating contractions along the large intestine, such as peristalsis and colonic migrating motor complexes in laboratory animals, particularly in guinea-pigs and mice. The first recordings of cyclical propagating contractions along the isolated whole human colon have now also been made. This review will highlight some of these advances and how impairments to these motility patterns may contribute to delayed colonic transit, known to exist in a proportion of patients with chronic constipation.
慢性便秘是一种高度使人虚弱的疾病，影响着社区中相当大的一部分人群。它给医疗保健系统带来了巨大的负担，并对患者的生活质量产生了巨大的影响。不幸的是，慢性便秘的病因尚不清楚，动物模型越来越多地被用于研究可能导致相关结肠感觉运动功能障碍的内在神经源性和肌源性机制。最近，我们对大肠中传播收缩的机制有了更多的了解，如实验室动物中的蠕动和结肠移行性运动复合波，特别是在豚鼠和小鼠中。现在也首次记录了沿着分离的整个人类结肠的周期性传播收缩。这篇综述将重点介绍其中的一些进展，以及这些运动模式的障碍如何导致已知存在于一部分慢性便秘患者中的结肠传输延迟。
