Migneco G, Tripi S, Navetta A, La Ferla A, Vaccaro F
Università degli Studi di Palermo, Cattedra di Fisiopatologia Medica.
Minerva Med. 1990 Jan-Feb;81(1-2):19-21.
The serum zinc concentration seems unlikely to be an important factor influencing immune response to hepatitis B vaccination in hemodialysis patients, on the basis of the following results: the absence of statistically significant differences in serum zinc concentrations between patients with absence of post-vaccine seroconversion or non protective seroconversion and patients with excellent seroconversion (anti-HBs concentrations over 124.6 mUI/ml); the association of protective antibody responses in 50% of non responders after an additional dose of HBV vaccine, without preliminary corrections of zinc balance.
基于以下结果，血清锌浓度似乎不太可能是影响血液透析患者对乙肝疫苗免疫反应的重要因素：疫苗接种后未发生血清转化或非保护性血清转化的患者与血清转化良好（抗-HBs浓度超过124.6 mUI/ml）的患者之间血清锌浓度无统计学显著差异；在未预先纠正锌平衡的情况下，额外一剂乙肝疫苗后50%的无反应者出现了保护性抗体反应。
