OPRM1和ABCB1单核苷酸多态性与术后疼痛中羟考酮反应缺乏相关性。

Lack of association of OPRM1 and ABCB1 single-nucleotide polymorphisms to oxycodone response in postoperative pain.

作者信息

Zwisler Stine T, Enggaard Thomas P, Mikkelsen Soeren, Verstuyft Céline, Becquemont Laurent, Sindrup Soeren H, Brosen Kim

机构信息

Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, DenmarkDepartment of Pharmacology, Faculty of Medicine Paris, University Paris-Sud, Paris, FranceDepartment of Neurology, Odense University Hospital, Odense, DenmarkClinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.

出版信息

J Clin Pharmacol. 2012 Feb;52(2):234-42. doi: 10.1177/0091270010397729.

DOI:10.1177/0091270010397729

PMID:21383334

Abstract

PURPOSE

The aim of the study was to search for an association between the single-nucleotide polymorphisms A118G in OPRM1 and C3435T and G2677T/A in ABCB1 and the analgesic effect of intravenous oxycodone in postoperative pain.

METHODS

There were 268 patients with postoperative pain after, primarily, thyroidectomy. At given times during the first 24 hours postoperatively, their pain was rated at rest and during activity according to a numeric rating scale (0 = no pain, 10 = worst possible pain) and calculated as pain time area under the curve0-24 hours . A negative answer in a final questionnaire and/or the use of rescue medication categorized a patient as a nonresponder.

RESULTS

For OPRM1, there was no difference found between the wild type and the variant allele in the percentages of nonresponders (118AA = 16.4% vs 118AG/118GG = 17.0%, P = 1.0) or in the pain ratings. For ABCB1, no difference was found between the wild type and the variant alleles for single-nucleotide polymorphism tested as percentages of nonresponders (3435CC = 17.5% vs 3435CT/3435TT = 15.8%, P = .85; 2677GG = 17.8% vs 2677GT/2677TT = 15.8%, P = .74) or pain ratings.

CONCLUSION

No association was found between the tested single-nucleotide polymorphisms in OPRM1 and ABCB1 and changes in the analgesic effect of oxycodone.

摘要

目的

本研究旨在探寻阿片受体μ1（OPRM1）基因单核苷酸多态性A118G以及ATP结合盒转运蛋白B1（ABCB1）基因单核苷酸多态性C3435T和G2677T/A与静脉注射羟考酮术后镇痛效果之间的关联。

方法

选取268例主要因甲状腺切除术后出现疼痛的患者。在术后24小时内的特定时间点，根据数字评分量表（0 = 无痛，10 = 剧痛）对其静息及活动时的疼痛进行评分，并计算0 - 24小时疼痛时间曲线下面积。最终问卷回答为阴性和/或使用了补救药物的患者被归类为无反应者。

结果

对于OPRM1，野生型和变异等位基因在无反应者百分比（118AA = 16.4% vs 118AG/118GG = 17.0%，P = 1.0）或疼痛评分方面均未发现差异。对于ABCB1，在作为无反应者百分比测试的单核苷酸多态性中，野生型和变异等位基因之间在疼痛评分方面也未发现差异（3435CC = 17.5% vs 3435CT/3435TT = 15.8%，P = 0.85；2677GG = 17.8% vs 2677GT/2677TT = 15.8%，P = 0.74）。