奥施康定药物遗传学对儿童术后镇痛及相关临床结局的影响：一项前瞻性初步研究。
Effects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children: a pilot prospective study.
机构信息
Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
Pharmacogenomics. 2023 Mar;24(4):187-197. doi: 10.2217/pgs-2022-0149. Epub 2023 Mar 22.
Variability in the pharmacokinetics and pharmacodynamics of oxycodone in children undergoing surgery could be due to genetic polymorphisms. The authors studied the association between clinical outcomes and pharmacogenes in children undergoing major surgery. A total of 89 children (35 undergoing pectus excavatum repair and 54 undergoing spinal fusion) were recruited. SNP rs6902403 showed an association with maximum pain score and total morphine equivalent dose (p < 0.05). Other polymorphisms in SNP, , and were also shown to be associated with average morphine equivalent dose, length of hospital stay and maximum surgical pain (p < 0.05). This study demonstrates novel associations between the above pharmacogenes and oxycodone's pharmacokinetics as well as postoperative outcomes in children. : NCT03495388 (ClinicalTrials.gov).
在接受手术的儿童中，羟考酮的药代动力学和药效动力学的可变性可能是由于遗传多态性所致。作者研究了在接受大手术的儿童中，临床结局与药物基因之间的相关性。共招募了 89 名儿童（35 名接受漏斗胸修复，54 名接受脊柱融合术）。SNP rs6902403 与最大疼痛评分和总吗啡等效剂量呈相关性（p < 0.05）。SNP 中的其他多态性 、 和 也与平均吗啡等效剂量、住院时间和最大手术疼痛呈相关性（p < 0.05）。这项研究证明了上述药物基因与羟考酮药代动力学以及儿童术后结果之间存在新的关联。NCT03495388（ClinicalTrials.gov）。
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