主动脉瓣反流兔心房利钠肽的分泌

Atrial natriuretic peptide secretion in rabbits with aortic regurgitation.

作者信息

Wainai Y, Kusuhara M, Yamada T, Yoshikawa T, Suzuki M, Hori S, Handa S, Yoshinaga K, Yamaguchi K

机构信息

Department of Internal Medicine, Keio University, School of Medicine, Tokyo, Japan.

出版信息

Res Exp Med (Berl). 1990;190(1):13-8. doi: 10.1007/pl00020001.

DOI:10.1007/pl00020001

PMID:2138349

Abstract

We investigated whether or not the extent of secretion of atrial natriuretic peptide (ANP) was altered during the chronic course of aortic regurgitation (AR) in rabbits. AR was induced by aortic valve perforation in 20 rabbits. Left ventricular end-diastolic pressure (LVEDP) was used as an index of the severity of heart failure. LVEDP and plasma immunoreactive(IR)-ANP were measured before and at 15 min, 1 week, and 4 weeks after induction of AR. In each period a correlation between LVEDP and plasma IR-ANP was observed, and the coefficients and covariances did not vary throughout the experiment. We conclude, therefore, that a chronic change in ANP secretion does not develop during the first 4 weeks after induction of AR in rabbits.

摘要

我们研究了兔主动脉瓣关闭不全（AR）慢性病程中，心房利钠肽（ANP）分泌程度是否发生改变。通过在20只兔身上进行主动脉瓣穿孔诱导AR。左心室舒张末期压力（LVEDP）用作心力衰竭严重程度的指标。在诱导AR前以及诱导后15分钟、1周和4周测量LVEDP和血浆免疫反应性（IR）-ANP。在每个时期均观察到LVEDP与血浆IR-ANP之间存在相关性，并且在整个实验过程中系数和协方差没有变化。因此，我们得出结论，在兔诱导AR后的前4周内，ANP分泌未发生慢性变化。