Satoh K, Masuda T, Masaki Y, Hasegawa N, Tsuyusaki T, Ando K, Marumo F, Kikawada R
Kitasato University School of Medicine, Kanagawa, Japan.
Am J Hypertens. 1990 Sep;3(9):704-6. doi: 10.1093/ajh/3.9.704.
To examine the role of the ventricle in ANP secretion, the atrial natriuretic peptide (ANP) concentration in the plasma, left atrial tissue and left ventricular tissue were observed in a canine during the course of experimental reversible mitral regurgitation (MR). For reversible MR, a basket catheter was inserted into the left atrium via the pulmonary vein and fixed at the mitral valve. The regurgitation arose when the tip basket wire was extended and disappeared immediately when it was closed. Left atrial pressure (LAP), right atrial pressure (RAP) and pulmonary artery pressure (PAP) increased significantly during MR, and decreased to the normal level after recovery from MR. Plasma ANP concentration showed a reversible change in correlation with LAP and RAP in each canine studied. The ANP level in the atrial and ventricular tissue decreased during MR, and the low levels were maintained after recovery from MR. Both the left arterial and left ventricular tissue ANP levels showed the same changes in acute MR. Therefore, it was suggested that normal ventricles might play a role in ANP secretion in acute MR.
为研究心室在心房利钠肽（ANP）分泌中的作用，在实验性可逆性二尖瓣反流（MR）过程中，观察了犬血浆、左心房组织和左心室组织中的心房利钠肽（ANP）浓度。对于可逆性MR，通过肺静脉将篮状导管插入左心房并固定在二尖瓣处。当篮状导管尖端的金属丝伸展时出现反流，当金属丝闭合时反流立即消失。MR期间左心房压力（LAP）、右心房压力（RAP）和肺动脉压力（PAP）显著升高，从MR恢复后降至正常水平。在每只研究的犬中，血浆ANP浓度呈现与LAP和RAP相关的可逆性变化。MR期间心房和心室组织中的ANP水平降低，从MR恢复后维持在低水平。急性MR时左心房和左心室组织中的ANP水平均呈现相同变化。因此，提示正常心室可能在急性MR的ANP分泌中起作用。
