MTHFD1L 基因 rs11754661 标记与西班牙人群的阿尔茨海默病无关。

The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population.

机构信息

Department of Structural Genomics, NeoCodex, Sevilla, Spain.

出版信息

J Alzheimers Dis. 2011;25(1):47-50. doi: 10.3233/JAD-2011-101983.

DOI:10.3233/JAD-2011-101983

Abstract

The MTHFD1L gene SNP variant rs11754661 was found to increase the risk of Alzheimer's disease in a recent Whole Genome Association Study. We have carried out an independent study of this genetic variant in 2467 individuals from Spain. We found no evidence of association between the MTHFD1L marker and susceptibility to Alzheimer's disease in our sample.

摘要

最近的全基因组关联研究发现，MTHFD1L 基因 SNP 变体 rs11754661 增加了阿尔茨海默病的风险。我们对来自西班牙的 2467 个人进行了这项遗传变异的独立研究。在我们的样本中，没有发现 MTHFD1L 标记与阿尔茨海默病易感性之间存在关联的证据。