MTHFD1L 基因 rs11754661 标记与中国汉族人群阿尔茨海默病的易感性相关。

The MTHFD1L gene rs11754661 marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population.

机构信息

Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

出版信息

J Neurol Sci. 2011 Sep 15;308(1-2):32-4. doi: 10.1016/j.jns.2011.06.036. Epub 2011 Jul 8.

DOI:10.1016/j.jns.2011.06.036

PMID:21741665

Abstract

Our objective is to evaluate the relationship between the rs11754661 polymorphism of the MTHFD1L gene and Alzheimer's disease (AD) in the ethnic Chinese Han. We conducted a case-control study (n=380, age>50) to determine the prevalence of one common single-nucleotide polymorphism (SNP) of MTHFD1L (rs11754661) in patients with AD in Chinese population of Mainland China, and clarified whether this polymorphism is a risk factor for AD. The prevalence of the minor allele (A) in the rs11754661 polymorphism was significantly different in AD patients and control subjects (P<0.01). The rs11754661 polymorphism was associated with AD in the ethnic Chinese Han (OR=1.829, 95% CI: 1.277-2.619, P=0.001), and the results were influenced by APOE status. Our data revealed that the allele (A) of the rs11754661 polymorphism within MTHFD1L gene may contribute to AD risk in the Chinese Han population.

摘要

我们的目的是评估 MTHFD1L 基因 rs11754661 多态性与汉族人群阿尔茨海默病（AD）之间的关系。我们进行了一项病例对照研究（n=380，年龄>50），以确定中国内地汉族人群 AD 患者中 MTHFD1L（rs11754661）常见单核苷酸多态性（SNP）的流行情况，并阐明该多态性是否为 AD 的危险因素。rs11754661 多态性中的次要等位基因（A）在 AD 患者和对照组中的分布差异具有统计学意义（P<0.01）。rs11754661 多态性与汉族人群 AD 相关（OR=1.829，95%CI：1.277-2.619，P=0.001），且结果受 APOE 状态影响。我们的数据表明，MTHFD1L 基因内 rs11754661 多态性的等位基因（A）可能导致汉族人群 AD 发病风险增加。