Mori Koichiro, Obara Yutaro, Moriya Takahiro, Inatomi Satoshi, Nakahata Norimichi
Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan.
Biomed Res. 2011 Feb;32(1):67-72. doi: 10.2220/biomedres.32.67.
The mushroom Hericium erinaceus has been used as a food and herbal medicine since ancient times in East Asia. It has been reported that H. erinaceus promotes nerve growth factor secretion in vitro and in vivo. Nerve growth factor is involved in maintaining and organizing cholinergic neurons in the central nervous system. These findings suggest that H. erinaceus may be appropriate for the prevention or treatment of dementia. In the present study, we examined the effects of H. erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Mice were administered 10 µg of amyloid β(25-35) peptide intracerebroventricularly on days 7 and 14, and fed a diet containing H. erinaceus over a 23-d experimental period. Memory and learning function was examined using behavioral pharmacological methods including the Y-maze test and the novel-object recognition test. The results revealed that H. erinaceus prevented impairments of spatial short-term and visual recognition memory induced by amyloid β(25-35) peptide. This finding indicates that H. erinaceus may be useful in the prevention of cognitive dysfunction.
自古以来，猴头菇在东亚地区就被用作食物和草药。据报道，猴头菇在体外和体内均可促进神经生长因子的分泌。神经生长因子参与维持和组织中枢神经系统中的胆碱能神经元。这些发现表明，猴头菇可能适用于预防或治疗痴呆症。在本研究中，我们检测了猴头菇对淀粉样β（25 - 35）肽诱导的小鼠学习和记忆缺陷的影响。在第7天和第14天给小鼠脑室内注射10μg淀粉样β（25 - 35）肽，并在23天的实验期内给它们喂食含有猴头菇的饲料。使用包括Y迷宫试验和新物体识别试验在内的行为药理学方法检测记忆和学习功能。结果显示，猴头菇可预防淀粉样β（25 - 35）肽诱导的空间短期记忆和视觉识别记忆损伤。这一发现表明，猴头菇可能对预防认知功能障碍有用。
