Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, LWL University Hospital, Ruhr-University Bochum, Bochum, Germany.
Mov Disord. 2011 Mar;26(4):671-8. doi: 10.1002/mds.23494. Epub 2011 Mar 7.
Huntington's disease (HD) is an autosomal dominant degenerative brain disorder that is characterized by motor, cognitive, and affective symptoms. There is, to some, degree, phenomenological overlap with schizophrenia. Schizophrenia patients are frequently impaired in "theory of mind" (ToM), that is, the ability to reflect on the mental states of self and others, with mixed evidence for a ToM deficit in HD.
We examined ToM and neurocognitive functioning in 25 patients diagnosed with HD. For comparison, 25 patients with schizophrenia and 25 healthy controls, matched for age and gender, were included.
Patients with HD were impaired in ToM relative to controls. The pattern of neurocognitive deficits including ToM strikingly resembled the one found in schizophrenia, suggesting a selectively impaired ToM. In contrast to previous schizophrenia research, ToM was not associated with functional measures on the Unified Huntington's Disease Rating Scale (UHDRS).
The present study shows that patients with HD have deficits in ToM similar to schizophrenia. The association of impaired ToM with function needs to be established in future studies using rating scales that more specifically address interpersonal problems.
亨廷顿病（HD）是一种常染色体显性退行性脑疾病，其特征为运动、认知和情感症状。在某种程度上，它与精神分裂症存在现象学上的重叠。精神分裂症患者经常在“心理理论”（ToM）方面受损，即反思自我和他人心理状态的能力，而在 HD 中存在 ToM 缺陷的证据则存在混合情况。
我们检查了 25 名被诊断患有 HD 的患者的 ToM 和神经认知功能。为了进行比较，我们纳入了 25 名精神分裂症患者和 25 名年龄和性别相匹配的健康对照组。
与对照组相比，HD 患者的 ToM 受损。包括 ToM 在内的神经认知缺陷模式与精神分裂症非常相似，表明存在选择性的 ToM 受损。与之前的精神分裂症研究不同，ToM 与统一亨廷顿病评定量表（UHDRS）上的功能测量无关。
本研究表明，HD 患者的 ToM 缺陷与精神分裂症相似。在使用更具体地解决人际问题的评定量表的未来研究中，需要确定 ToM 受损与功能的关联。
Zotero 插件