蒙特利尔认知评估作为亨廷顿病认知功能障碍的筛查工具。
The Montreal Cognitive Assessment as a screening tool for cognitive dysfunction in Huntington's disease.
机构信息
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
出版信息
Mov Disord. 2010 Feb 15;25(3):401-4. doi: 10.1002/mds.22748.
Cognitive dysfunction is one of the hallmarks of Huntington's disease (HD) and may precede the onset of motor symptoms. The Montreal Cognitive Assessment (MoCA), a brief cognitive screening instrument with high specificity and sensitivity for detecting early cognitive impairments, has not been studied in the HD population. In this study, we compare the MoCA with the mini-mental state examination (MMSE) as a screening tool for cognitive dysfunction among 53 patients with HD. The mean MMSE score was 26 +/- 2.4, and mean MoCA score was 21 +/- 4.4. Twenty-one patients (81%) of those who scored >or=26 on the MMSE had the MoCA score <26. Thirty-two patients (78%) of those who scored >or=24 on the MMSE had the MoCA score <24. The MoCA may be a more sensitive screening tool for cognitive impairments in HD relative to the MMSE.
认知功能障碍是亨廷顿病（HD）的特征之一，并且可能先于运动症状出现。蒙特利尔认知评估（MoCA）是一种简短的认知筛查工具，具有很高的特异性和敏感性，可用于检测早期认知障碍，但尚未在 HD 人群中进行研究。在这项研究中，我们将 MoCA 与简易精神状态检查（MMSE）进行比较，作为筛查 53 例 HD 患者认知功能障碍的工具。平均 MMSE 评分为 26 +/- 2.4，平均 MoCA 评分为 21 +/- 4.4。在 MMSE 评分> = 26 的患者中，有 21 名（81％）的 MoCA 评分<26。在 MMSE 评分> = 24 的患者中，有 32 名（78％）的 MoCA 评分<24。与 MMSE 相比，MoCA 可能是一种更敏感的筛查 HD 认知障碍的工具。
Zotero 插件