van der Tempel H, Tulleken J E, Limburg P C, Muskiet F A, van Rijswijk M H
Department of Rheumatology, State University Groningen, The Netherlands.
Ann Rheum Dis. 1990 Feb;49(2):76-80. doi: 10.1136/ard.49.2.76.
Sixteen patients with rheumatoid arthritis entered a trial to determine the clinical and biochemical effects of dietary supplementation with fractionated fish oil fatty acids. A randomised, double blind, placebo controlled crossover design with 12 week treatment periods was used. Treatment with non-steroidal anti-inflammatory drugs and with disease modifying drugs was continued throughout the study. Placebo consisted of fractionated coconut oil. The following results favoured fish oil rather than placebo: joint swelling index and duration of early morning stiffness. Other clinical indices improved but did not reach statistical significance. During fish oil supplementation relative amounts of eicosapentaenoic acid and docosahexaenoic acid in the plasma cholesterol ester and neutrophil membrane phospholipid fractions increased, mainly at the expense of the omega-6 fatty acids. The mean neutrophil leucotriene B4 production in vitro showed a reduction after 12 weeks of fish oil supplementation. Leucotriene B5 production, which could not be detected either in the control or in the placebo period, rose to substantial quantities during fish oil treatment. This study shows that dietary fish oil supplementation is effective in suppressing clinical symptoms of rheumatoid arthritis.
16名类风湿性关节炎患者参与了一项试验，以确定补充分馏鱼油脂肪酸的饮食对临床和生化指标的影响。该试验采用随机、双盲、安慰剂对照交叉设计，治疗期为12周。在整个研究过程中，患者继续使用非甾体抗炎药和病情改善药物。安慰剂由分馏椰子油组成。以下结果表明鱼油优于安慰剂：关节肿胀指数和晨僵持续时间。其他临床指标有所改善，但未达到统计学显著性。在补充鱼油期间，血浆胆固醇酯和中性粒细胞膜磷脂组分中二十碳五烯酸和二十二碳六烯酸的相对含量增加，主要是以ω-6脂肪酸为代价。补充鱼油12周后，体外中性粒细胞白三烯B4的平均生成量有所减少。白三烯B5的生成在对照期和安慰剂期均未检测到，但在鱼油治疗期间大幅增加。这项研究表明，补充饮食鱼油对抑制类风湿性关节炎的临床症状有效。
